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Heparin is contraindicated in patients known to have hypersensitivity to heparin. It is also contraindicated when suitable blood coagulation tests - e.g. the whole-blood clotting time, partial thromboplastin time - cannot be performed at the required intervals. There is usually no need to monitor the effect of low-dose heparin in patients with normal coagulation parameters. The drug is contraindicated during any uncontrolled active bleeding state (see Warnings).
Heparin without preservatives should be used in premature infants.
